Maternal Fetal Medicine
Zahra Panahi; Seyedeh Noushin Ghalandarpoor-Attar; Azade Shabani; Mamak Shariat; Fahimeh Ghotbizadeh; Sedigheh Hantoushzadeh; Elham Feizabad; Seyedeh Mojgan Ghalandarpoor-Attar
Volume 7, Issue 6 , September and October 2022, , Pages 536-542
Abstract
Background & Objective: The thymus gland significantly affects fetal immune system maturation. Additionally, there is a linear association between thymus gland size and its performance. Given the high prevalence of vitamin D deficiency in Iran and scarce studies with conflicting results, subjecting ...
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Background & Objective: The thymus gland significantly affects fetal immune system maturation. Additionally, there is a linear association between thymus gland size and its performance. Given the high prevalence of vitamin D deficiency in Iran and scarce studies with conflicting results, subjecting maternal vitamin D concentration effect on fetal thymus, we decided to investigate maternal vitamin D concentration and its relation to fetal thymus size in mid-gestation. This study also aimed to generate a race-specific reference range.Materials & Methods: We performed a cross-sectional study of ultrasound measurements of the fetal thymus at 18-22 weeks of gestational age in 94 pregnant women and its correlation with maternal serum vitamin D levels from May to July 2021 at the tertiary center of Imam Khomeini Hospital in Tehran, Iran.Results: The mean values of thymus perimeter, thymus-thoracic ratio, thymus transverse diameter, and thymus area in all participants were 4.18±0.56 cm, 0.37±0.04, 1.56±0.21 cm, and 1.11±0.76 cm2, respectively. There was a trend toward decreased thymus perimeter and transverse thymus diameter with decreasing level of maternal vitamin D. There was also a significant correlation between thymus perimeter and transverse thymus diameter with fetal biometric indices and gestational age. Furthermore, a significant correlation was observed between the thymus perimeter and transverse thymus diameter. Conclusion: We generated a race-specific nomogram for fetal thymus size in Iranian pregnant women. Moreover, the observed trend toward decreased fetal thymus size with decreasing maternal vitamin D levels requires further prospective investigations. A high prevalence of vitamin D deficiency and low compliance with daily vitamin D intake during pregnancy was also shown, which requires a solution.
Maryam Deldar Pasikhani; Fahimeh Ghotbizadeh; Razieh Akbari; Mahshid Shooshtari; Atieh Pajouhi
Volume 4, Issue 4 , September and October 2019, , Pages 151-154
Abstract
Background & Objective: Anticoagulant therapy has been used for the prevention and treatment of deep vein thrombosis and pulmonary embolism. Heparin-induced necrotizing skin lesion is a serious complication that can be potentially life-threatening.
Case Report: We report a 55-year-old female presenting ...
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Background & Objective: Anticoagulant therapy has been used for the prevention and treatment of deep vein thrombosis and pulmonary embolism. Heparin-induced necrotizing skin lesion is a serious complication that can be potentially life-threatening.
Case Report: We report a 55-year-old female presenting with skin necrosis without thrombocytopenia after prescribing heparin prophylaxis. She had died as it was not possible to discontinue her heparin therapy.
Conclusion: Heparin-induced skin necrosis should be suspected in all patients who undergo UFH or LMWH. Observation of platelet count is recommended at the onset of skin lesions. Early diagnosis of this condition can be helpful for the management of this potentially mortal disease.
Fahimeh Ghotbizadeh Vahdani; Sedigheh Hantoushzadeh; Maryam Deldar Pasikhani; Azin Ghamari; Maryam Hajatpour; Zahra Panahi
Volume 4, Issue 2 , May and June 2019, , Pages 51-56
Abstract
Background & Objective: Due to increased rate of risk factors, the incidence of placenta accreta (PA) is increasing worldwide. This study aimed to investigate the important factors regarding the occurrence of PA, as well as outcomes and complications of Trans Abdominal Hysterectomy (TAH) in the patients ...
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Background & Objective: Due to increased rate of risk factors, the incidence of placenta accreta (PA) is increasing worldwide. This study aimed to investigate the important factors regarding the occurrence of PA, as well as outcomes and complications of Trans Abdominal Hysterectomy (TAH) in the patients with PA.
Materials & Methods: The study was performed as an observational cross-sectional study. Between March 2011 and March 2017, 177 patients, known cases of PA that undergone TAH, were enrolled in our study. Extracted data include demographic characteristics, patient’s medical history, surgical approach and complications, such as blood loss and urologic problems.
Results: The average of maternal age and gestational age were 33.6±4.70 (range= 22-43) years and 34.6±3.16 weeks, respectively. Neither maternal age (P < /em>=0.652) nor BMI (P < /em>=0.659) had significant association with abnormal placentation. Previous history of dilation & curettage (D&C) was found in 34 patients that was not related to the occurrence of the PA (P < /em>=0.508).Twenty-one (11.9%) of the patients needed urological intervention that did not associated with placental position, skin and uterine incision (P < /em>=0.258, 0.410 and 0.219). There is no relation between amount of blood loss with gestational age (P < /em>=0.7) and number of C/S (P < /em>=0.4), gestational age (P < /em>=0.7), anesthesia (P < /em>=0.2), and curettage history (P < /em>=0.3).
Conclusion: Our mortality and morbidity rate is much lower than reported ones, indicating the high-level ability, skill and knowledge of the surgeons.
Sedigheh Borna; Nasim Khorami; Azin Ghamari; Fahimeh Ghotbizadeh Vahdani
Volume 4, Issue 1 , March and April 2019, , Pages 24-28
Abstract
Background & Objective: This prospective study aimed to determine the relationship between maternal and amniotic fluid (AF) lipid profiles in the second trimester with pregnancy outcomes.
Materials & Methods: One hundred-eighty singleton pregnant women, with a gestational age of 16-22 weeks, ...
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Background & Objective: This prospective study aimed to determine the relationship between maternal and amniotic fluid (AF) lipid profiles in the second trimester with pregnancy outcomes.
Materials & Methods: One hundred-eighty singleton pregnant women, with a gestational age of 16-22 weeks, were enrolled in this study. All women underwent amniocentesis, and 2 mL of AF was investigated for AF lipid profile. Furthermore, the serum maternal lipid profile was evaluated simultaneously. All participants were followed up until the delivery, and postnatal outcomes were recorded.
Results: Mean maternal age and body mass index (BMI) of all participants were 5.8±33 years and 25.6±2.8 kg/m2, respectively. Mean maternal estriol, cholesterol, and triglyceride levels, as well as mean cholesterol and triglyceride levels of AF, were significantly different between term and preterm; intrauterine growth retardation (IUGR) and non-intrauterine growth retardation (non-IUGR); and low birth weight and normal weight neonates (P < /em><0.001). The AF cholesterol level was an independent predictor of term or preterm delivery, while the maternal estriol level was an independent predictor of IUGR or normal growth.
Conclusion: Maternal and amniotic fluid lipid profiles could be good indicatives of fetus growth.